Sunday, September 09, 2007

Spot The Mistake

First, read this bit to get an idea of what the drug Coumadin (warfarin), a blood thinner, does:

Warfarin, sold under the brand name Coumadin, prevents blood clots and reduces the risk of stroke in patients with atrial fibrillation, artificial heart valves, deep venous thrombosis and pulmonary emboli. It is also used to prevent clots in people who recently had certain orthopedic surgeries.


So, Coumadin works to prevent clots. It makes the blood more flowy if you will.

Now, knowing that, see if you can spot the mistake in the article:

FRIDAY, Sept. 7 (HealthDay News) -- A new gene-based dosing formula for the anti-clotting drug warfarin should make it easier to prescribe the correct dose of the blood thinner, researchers say.

Up to this point, doctors have had to engage in a trial-and-error process over several weeks that left patients at risk of hemorrhaging from low doses or developing blood clots with too-high doses.

"We already knew these genes affected warfarin dosing, but we didn't know how to use that information clinically," researcher Dr. Brian Gage, medical director of Barnes-Jewish Hospital's Blood Thinner Clinic, said in a prepared statement. "But with this study, we've established a simple way to combine these genetic factors with clinical factors in a dosing algorithm."

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3 Comments:

At 3:07 AM, Blogger ctate said...

Hemorrhaging would arise from a too-high dose, not low doses. They mixed up their effects.

They also don't talk about how warfarin has a long-established history as rat poison. It's nasty, dangerous stuff. And keeping things on-topic for this blog, I'm told that menstruation while taking it is also Hell On Earth.

(Anti-coagulant + uterine bleed... think about it.)

 
At 3:37 AM, Blogger ema said...

ctate,

Spot on!

 
At 7:01 AM, Anonymous Anonymous said...

Wow, even knowing that there was an error in that paragraph, my eyes slid right over the "high dose" "low dose" mixup, correcting it without even thinking.

Interesting, how the mind works.

 

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